Control Engineering Concepts in Systems- and Synthetic Biology

Control theory has been successfully applied in engineering to build stable and reliably behaving devices. How can concepts developed in control engineering help us understand regulation in biological systems and how to develop reliable, integrated medical devices? In this workshop we will present and discuss some of the existing and novel concepts of control theory and how they can be applied in biotechnology and medical engineering.​

Understanding principles of how biological systems maintain their function in response to environmental perturbations is fundamental to understand the physiology of organisms, how to manipulate them in a biotechnological context, or how to re-establish homeostatic control in disease. Principles from control engineering have been applied to derive fundamental understanding of how homeostasis is achieved or may become disrupted in biological systems. Conversely, biological systems may provide ideas of novel means to create robust regulatory mechanisms that can improve engineering. The workshop aims to present basic principles as well as novel developments in this field. It also aims to show how control engineering principles can be linked to mechanistic molecular kinetics. Thus, quantitative measures of control can be formulated in terms of molecular properties. This will allow a quantitative description of how molecular mechanisms orchestrate regulation of biological processes.

The workshop is organized by Peter Ruoff, Tormod Drengstig and Kristian Thorsen at the University of Stavanger in collaboration with the Centre for Digital Life Norway. The workshop is supported by the National research school for bioinformatics, biostatistics and systems biology (https://norbis.w.uib.no/) and the Digital Life Norway research school (https://digitallifenorway.org/dlnrs). Members of these research schools may apply for support for travel and accommodation costs for attending this workshop.

Confirmed speakers

Olivier Bernard, BIOCORE, INRIA, France

Brian Ingalls, University of Waterloo, Canada

Krishnan, Imperial College of London, UK

Hans Stigter, Wageningen University, Netherlands

Jens Timmer, University of Freiburg, Germany


Register using this link.

Tentative program

(Subject to modifications based on invited speakers and participants)

Day 1:

0900 - 1200 Session 1, morning, Principles for control and regulation in biological systems

0900-0915 Welcome session 1
0915-1000 Regulation, principles and applications in physiology
1000-1015 Coffee break
1015-1100 Overview control structures and controller motifs
1105-1130 Open short talk
1135-1200 Open short talk or alternatively a discussion session

1200-1300 Lunch

1300 - 1645 Session 2, afternoon, Understanding and manipulating the internal systems for sensing and control in biological systems, systems and synthetic biology

1300-1315 Welcome session 2
1315-1400 Design and implementation of control systems in living cells
1400-1430 Open short talk
1430-1500 Coffee break
1500-1545 Open long talk or alternatively presentation of a project/proposed project with feedback and comments from the audience.
1545-1615 Open short talk or alternatively a discussion session
1615-1645 Open short talk or alternatively a discussion session

Social + dinner

1900 - 2200

Day 2:

0900 - 1200 Session 3, morning, Adding external control to biological systems, artificial life and biomedical engineering

0900-0915 Welcome session 3
0915-1000 Artificial pancreas, or artificial limb control projects
1000-1015 Coffee break
1015-1100 Open long talk or alternatively presentation of a project/proposed project with feedback and comments from the audience.
1105-1130 Open short talk
1135-1200 Open short talk or alternatively a discussion session

1200-1300 Lunch

1300 - 1610 Session 4, afternoon, Model reduction, indentifiability, observability

1300-1315 Welcome session 4
1315-1400 Invited talk
1400-1430 Open short talk
1430-1500 Coffee break
1500-1545 Open long talk or alternatively presentation of a project/proposed project with feedback and comments from the audience.

Day 3 (optional):

Social trip: Hike to the Pulpit rock (picture from Visit Norway).

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Information about the event

  • Time:
    20. — 21. May 2019
  • Place:
    Måltidets Hus, UiS
  • Event type:
    Forskerskolen
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Contact

#Forskerskolen #Workshop #Konferanse / Workshop #Research School