Application deadline: 19 October, 2017 3-year Postdoctoral fellow position now available the Norwegian Centre for Mental Disorders Research (NORMENT). The successful candidate will explore the effects of genetic variation in iPSC-derived neurons by means of electrophysiological techniques for testing and validation of neuron models.
Position as postdoctoral research fellow available at the Norwegian Centre for Mental Disorders Research (NORMENT) and in the research group of Professor Srdjan Djurovic.
The fellowship period is three years.
Within the framework of the position duties may be assigned. No one can
be appointed for more than one Postdoctoral Research Fellowship at the
University of Oslo.
Somatic cells can be directly reprogrammed in vitro into a pluripotent embryonic stem cell-like state. These iPSCs, commonly generated from human fibroblast cells, are nearly identical to embryonic stem (ES) cells in gene expression, DNA methylation and chromatin modifications. By differentiating these disorder-specific iPSCs into neurons, we aim to identify specific neuronal abnormalities associated with SCZ and BD in human patients. Experimentally measured parameters describing neuronal excitability and synaptic function will directly map on to electrophysiological characteristics identified in the computational modelling project. In parallel, we will obtain gene expression profiles (RNA Seq), to characterize the different mRNA patterns of the iPSC-derived neurons, and splice variants.
The post doc will work in a project funded by the Research Council of Norway – DigiBrain programme. The primary objective of this project is to gain more knowledge about mechanisms of severe mental disorders, by identifying molecular and cellular phenotypes that are associated with severe mental illness, using the well characterized TOP (Thematically Organized Psychosis) sample. The candidate will join the group experienced with iPSC differentiation. The derived cells will be subjected to rigorous validation utilizing already established protocols. These will include transcriptome analysis, immunohistochemistry, FACS, neurite analysis, synaptic protein staining analysis and synapse density, as well as electrophysiology (whole-cell patch clamp recordings and multiphoton Ca2+ imaging).
How to apply:
The application must include:
The application with attachments must be delivered in our electronic recruiting system, please follow the link “apply for this job”. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English or a Scandinavian language.
Interviews with the best qualified candidates will be arranged.
For more information about the project, please contact:
Professor Ole Andreassen: phone + 47 990 38 893, firstname.lastname@example.org
Professor Srdjan Djurovic: phone 22 11 98 90 email@example.com
Publisert: 16. Oct 2017 - kl. 16:27
Sist oppdatert: 16. Oct 2017 - kl. 16:30