Recent years have seen a huge change in the way we view the intracellular environment, resulting in some past definitions for organelles being re-written. In this talk, associate professor Sushma Grellscheid from CBU and Department of Biological Sciences, UiB, will give an introduction to this rapidly developing multidisciplinary area of cell biology and physics, and describe an approach for in-vivo measurement of organelle surface tension.
This lecture in the Digital frukost seminar series is open for everyone.
Due to the current Covid-19 situation, the lecture will only be available digitally. Note that only registered participants will get access to the link.
Deadline for registration: November 15
Register to join the meeting here
This seminar will present the story of working on an interdisciplinary, collaborative project involving cell biology, computational modelling and soft matter physics. Recent years have seen a huge change in the way we view the intracellular environment, resulting in some past definitions for organelles being re-written. We now recognise that organelles may be liquid droplets in addition to the solid structures we are familiar with. They may also be dynamically assembled and disassembled in response to the cellular environment. Stress granules are such an example, and unlike classical organelles, they are not membrane bound and arise from liquid-liquid phase separation triggered by oxidative, temperature or osmotic stress. They disassemble and mix back into the cytoplasm once the relevant stress is resolved. Stress granule components have long been known to form solid aggregates in neurodegenerative disease and it has been hypothesised that the change in state from liquid to solid is pathologically relevant. An important open problem in this field is that despite its importance in cellular homeostasis and implications for disease, there are few methods for measuring the material properties of these droplet organelles. This seminar will first introduce this rapidly developing multidisciplinary area of cell biology and physics, and then present our contributions to it. We have developed a novel approach for in-vivo measurement of surface tension of stress granules within living cells using a combination of live cell microscopy, molecular biology, computational modelling and soft matter physics.
"Digital Frukost" is an open breakfast seminar series focusing on research activities at the interface between the biological sciences and that of mathematics, computer science, physics, engineering or social sciences. Examples of such research activities could be mathematical or computational modeling of biological systems, application of engineering/control systems theory on biological systems or inspired by biological systems, application of mathematics/statistics/machine learning to analyze big data in health or marine sector; from sensor systems, imaging, omics technologies, policy making based on scientific models etc.
We look forward to your participation!